Core Outcome Measures for Post-Covid condition/Long Covid study registration in Core Outcome Measures in Effectiveness Trials (COMET) database
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has placed a significant burden on public health worldwide. As of end of March 2021, there have been an estimated 125 million cases of coronavirus disease 2019 (COVID-19) globally. The acute presentation of COVID-19 has now been widely investigated and risk factors for in-hospital mortality identified.

It has now become evident that a significant portion of those with COVID-19 subsequently experience lasting symptoms including fatigue, breathlessness and neurological complaints months after the acute infection. This is now commonly referred to as Long COVID but has also been described as post-COVID syndrome or COVID long-haulers. Recently published the UK National Institute for Health and Clinical Excellence (NICE) COVID-19 guideline call infection sequalae “Post-COVID-19 syndrome”, defining it as “signs and symptoms that develop during or after an infection consistent with COVID-19, continue for more than 12 weeks and are not explained by an alternative diagnosis”. Interim definitions for the COVID-19 sequelae are, however, based on limited evidence from small cohorts with short-term follow-up. The World Health Organization at a recent global forum called countries to prioritise rehabilitation for the consequences of COVID-19, collect harmonised information on Long Covid and proposed the term “Post-Covid condition”.

There is an urgent need to optimise and standardise outcome measures for this important and emerging patient group both for clinical services and for research, especially clinical trials, to allow comparing and pooling of data. The aim of this project is to rapidly define a core outcome set (COS) for Post-Covid condition/Long Covid for both clinical (from low to high resource settings) and research use.

Daniel Munblit, Sechenov University, Moscow, Russia/ Imperial College London, London, UK
Timothy Nicholson, King's College London, London, UK
Paula Williamson, University of Liverpool, UK
Christian Apfelbacher, University of Magdeburg, Germany
Piero Olliaro, ISARIC, University of Oxford, UK
Theo Vos, University of Washington, Seattle, USA
Margaret Herridge, University of Toronto, Canada
Dale Needham, Johns Hopkins University, USA
John Marshall, University of Toronto, Canada
Louise Sigfrid, ISARIC, University of Oxford, UK
Jochen Schmitt, University Dresden, Germany
Frances Simpson, University of Coventry, UK
Calum Semple, University of Liverpool, UK
John O Warner, Imperial College London, London, UK
Allison Tong, The University of Sydney, Australia
Janet Scott, University of Glasgow, UK
Jon Genuneit, University of Leipzig, Germany
Nina Seylanova, Sechenov University, Moscow, Russia
Alisa Kokorina, Pirogov University, Moscow, Russia
Callum Parr, Imperial College London, London, UK
Jessica Chen, Imperial College London, London, UK
Alla Guekht, Research and Clinical Center for Neuropsychiatry, Moscow, Russia
Audrey DunnGalvin, University of Cork, Ireland
Wouter De Groot, World Health Organization

Further Study Information
Current Stage: Ongoing
Date: March 2021 - March 2022
Funding source(s): No external funding
Made on